Researchers at The University of Texas MD Anderson Cancer Center have identified a potential breakthrough in the fight ...

New gene therapy modalities, such as CRISPR guide RNA (single guide ribonucleic acid [sgRNA]) and messenger RNA (mRNA), ...

Legumain 在癌症中的作用复杂多样，在不同肿瘤中表现出不同的预后意义。在 ccRCC 中，其蛋白水平在肿瘤组织中升高，但成熟形式减少，且尿中水平与肿瘤转移状态相关，这表明其细胞定位的调节可能参与 ccRCC 的恶性进展。Legumain 的分泌和功能受到多种因素的调控，包括氧化还原状态、翻译后修饰等。本研究发现的 His343 氧化位点在 prolegumain ...

Applied DNA Sciences Inc (NASDAQ:APDN) reported its financial results for the first quarter of fiscal year 2025, showcasing a notable increase in revenue but also highlighting ongoing challenges with ...

Despite the established links between inflammation and cancer development, the effects of inflammatory signaling on cancer ...

本研究利用转基因小鼠模型，明确了 ACOT12 在肾脏疾病（尤其是肾脏纤维化）发病机制中的生物学功能。ACOT12 作为脂质代谢和肾脏纤维化的关键调节因子，其缺乏会加剧肾脏纤维化，可能是通过下调 pexophagy 实现的。

Direct chemical synthesis has been adapted to make oligonucleotides of remarkable length, including an 800 nucleotide green ...

Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). Here, using a ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

Aims Clopidogrel is the most commonly prescribed thienopyridine as part of dual anti-platelet therapy for the treatment of ...