Chronic liver damage in BMP-9-deficient mice or in mice adenovirally overexpressing the selective BMP-9 antagonist activin-like kinase 1-Fc resulted in reduced deposition of collagen and subsequent ...

Objectives Tissue fibrosis is a major hallmark and a leading cause of death in systemic sclerosis (SSc). Here, we investigated the antifibrotic effects of pomalidomide, an analogue of thalidomide with ...

[78] Several potent non-selective tyrosine kinase inhibitors that interrupt both VEGF and PDGF signaling have been approved for cancer therapy: imatinib, sorafenib, pazopanib, sunitinib ...

In the subarachnoid space, CTGF contributes to pia mater fibrosis by promoting the synthesis and deposition of extracellular matrix components. In the non-canonical Smad signaling pathway, the ...

Figure 1. Overview of TAO pathogenesis. TAO treatment focuses on reducing orbital inflammation, alleviating exophthalmos, improving appearance, inhibiting the fibrosis of extraocular muscles, orbital ...

It is now well established that PSC are responsible for producing the stromal reaction (fibrosis) of two major diseases of the pancreas—chronic pancreatitis and pancreatic cancer. Despite ...

[20] Fibrosis and its extension in hepatic tissue is most common evidence of cirrhosis. Several indexes are available to predict cirrhosis but no method or score is available on exclusive basis to ...