Additionally, we Preliminary observed and validated whether THBS1 overexpression could rescue nerve cell damage and the abnormalities in PI3K-AKT and TGF-β signaling pathways. Results: Entrectinib ...

Despite the established links between inflammation and cancer development, the effects of inflammatory signaling on cancer ...

College of Life Sciences, Key Laboratory of Animal Reproduction and Biotechnology in Universities of Shandong, Qingdao Agricultural University, Qingdao 266109, China ...

School of Public Health, Jilin University, Changchun, Jilin, 130021, P. R. China ...

Celcuity's gedatolisib, a dual PI3K/mTOR inhibitor, shows promise in Phase 3 breast cancer trials. Click here to read an ...

Aim: Inflammation and fibrosis have been shown to be critical factors in heart failure (HF) progression. Calycosin (Cal) is the major active component of Astragalus mongholicus Bunge and has been ...

为解决骨肉瘤治疗难题，武汉大学人民医院的研究人员开展 HMGCL 在骨肉瘤中作用的研究。结果发现 HMGCL 可抑制骨肉瘤进展，或为新治疗靶点。推荐科研读者阅读，助于了解骨肉瘤治疗新方向，开拓研究思路。

This is regulated through activation of the AKT signaling pathway. Loss of Ezrin was not sufficient to repress TSC complex by EGF and culminated in translocation of TSC complex to lysosomes triggering ...

在构建 NAFLD 球体模型后，研究人员发现，球体在培养过程中逐渐形成了正常肝细胞的形态。FFA 刺激会抑制球体活力，而褐藻糖胶处理后，球体活力明显恢复。同样，FFA 会使球体中 TG 含量升高，褐藻糖胶则能让它降下来，油红 O 染色也再次证实了褐藻糖胶可以抑制球体中的脂质积累。这些结果充分表明，褐藻糖胶就像一位 “减脂小能手”，能够有效改善 FFA 诱导的脂质积累问题。