Despite the established links between inflammation and cancer development, the effects of inflammatory signaling on cancer ...

Celcuity's gedatolisib, a dual PI3K/mTOR inhibitor, shows promise in Phase 3 breast cancer trials. Click here to read an ...

The main goal of our laboratory is the identification and characterization of signal transduction pathways that cause the dysregulation of growth and inhibition of apoptosis that characterize advanced ...

Aspirin reduced colorectal cancer recurrence risk by 50% in patients with PIK3CA mutations over three years. Mutations in the PI3K pathway predict aspirin response, broadening its use to more patients ...

The mechanistic (or mammalian) target of rapamycin (mTOR) signaling pathway ... anti-depressive effect was produced through the PI3K and mTOR pathway. The IL-PFC in rodents is considered ...