Background: The mechanisms by which intracranial atherosclerosis (ICAS) contributes to large-vessel occlusion strokes (LVOS) remains unclear. Our investigation focused on delineating the distinctive ...

The understanding of the pathophysiology of atherosclerosis and related vascular diseases has changed over the last decade, providing new perspectives for preventive and therapeutic strategies.

Lipid accumulation and inflammation play a crucial role in the pathogenesis of atherosclerosis. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are an emerging lipid-lowering agent ...

Background Left ventricular (LV) mass is closely associated with atherosclerotic heart disease, but the mechanisms are not well defined. This study aimed to evaluate the risk factors associated with ...

Atherosclerosis (AS) is the main pathological basis for the development of cardio ... AS is a systemic chronic inflammatory disease with complicated pathogenesis. Efferocytosis involves the regulation ...

However, whether LKB1 also affects the functional plasticity of macrophages in atherosclerosis has not attracted much attention. Abnormal macrophage function is a pathophysiological hallmark of ...

A study published by researchers from the Sant Pau Research Institute (IR Sant Pau) and the Stroke Unit of Sant Pau Hospital in the Journal of Lipid Research provides new evidence on the essential ...

These included the brachial and distal external carotid arteries, vessels usually immune from atherosclerosis. [36] The findings do lend support to the view that there is a generalized dilating ...

A common genetic pathway may account for increased risk for atherosclerotic disease in patients with chronic widespread musculoskeletal pain.