HAP is a representative example of a canonical CAM, that targets a hydrophobic pocket mediating HBc-dimer multimerization, an essential step in capsid assembly. A blue arrow indicates how dimeric ...

We synthesized a geranyl dimer that binds to the central pocket with micromolar affinity, and dimeric peptides that bind the spike-tip pocket with sub-micromolar affinity. Cryo-electron microscopy ...