Widespread alterations in RNA processing (splicing, polyadenylation, decay, etc.) are common in dynamic cell states during development and malignancy. For example, many cancers harbor elevated levels ...

In this case, the degradation or processing of a given RNA substrate would be achieved ... component of the pre-mRNA cleavage and polyadenylation machinery. Future work involving a combination ...

Yet, sometimes 3'-end processing factors start polyadenylation earlier in the transcript ... that is designed to empower scientists mapping the RNome and advance our overallunderstanding of RNA. Tecan ...

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...

RNA breaks destined for repair are inflicted by sequence-specific or structure-specific endoribonucleases during physiological RNA processing (e.g. tRNA splicing; kinetoplast mRNA editing) and under ...

which binds to specific promoter regions on the DNA and initiates the synthesis of the complementary RNA strand. The resulting primary transcript, known as pre-mRNA in eukaryotes, undergoes several ...

regulates alternative cleavage and polyadenylation of mRNAs. "Our team has identified a gap in knowledge around the RNA-binding capabilities of C2H2 zinc finger proteins," said Jack Greenblatt ...