Notably, DNA methylation, an important epigenetic regulatory mechanism, often manifests as global hypomethylation or hypermethylation of specific gene promoter regions in BC. Alterations in this ...

The high accuracy or fidelity of semi-conservative DNA replication is the product of nucleotide template interaction, polymerase-enhanced base selectivity, exonuclease proofreading and the post ...

Single-cell DNA methylation sequencing technology has brought new perspectives to investigate epigenetic heterogeneity, supporting a need for computational methods to cluster cells based on ...