Protein kinase research presents an opportunity to explore molecular targets in the body to treat diseases like cancer and ...

Mammalian AMP-activated protein kinase (AMPK) was discovered as a protein kinase that switches off lipid synthesis. The yeast orthologue, the SNF1 complex, was discovered in screens for mutations ...

A new study reveals a possible protein misfolding mechanism that may resolve a long-standing mystery of why certain proteins ...

Proteins are long molecules that must fold into complex three-dimensional structures to perform their cellular functions.

A new study demonstrates a potential protein misfolding mechanism that could solve a decades-old mystery of why some proteins ...

Protein kinase inhibitors have revolutionized cancer treatment by targeting specific kinases involved in tumor growth and survival. As of 2024, over 80 small-molecule protein kinase inhibitors have ...

Researchers have unveiled the first real look at a mitochondrial protein strongly linked to Parkinson's disease, revealing ...

This new cryo-EM structure represents a remarkable advance in our understanding of how human PINK1 is stabilized” said ...

Genentech Inc. has disclosed molecular glue compounds with the ability to induce cyclin-dependent kinase 2 (CDK2)/protein cereblon (CRBN) interaction for CDK2 degradation reported to be useful for the ...