Active caspase 1 causes pyroptosis and is responsible ... stimulate adaptive immune responses and enhance host survival; however, inappropriate activation of caspase 1 can lead to pathological ...

The decrease in CD4 cells during HIV infection seems to be driven by immune activation, which does not always correlate with viral load. Experienced clinicians are all too familiar with the ...

Neutrophils play a crucial role in the immune response, acting as the most abundant white blood cells responsible for frontline defense against infections ...

In a study published today (October 20) in Science Translational Medicine, researchers show that these cells, the most abundant in circulation, also alert the immune system to the presence of bacteria ...

In a study of the immune systems of mice, scientists at Johns Hopkins Medicine say they have found a new role for a protein, QRICH1, which could become a target for drugs to dial up or down the ...

Unlike traditional immunotherapy, which can cause broad immune activation and unwanted side effects, AP-EVs provide precise targeting of tumor-fighting T cells, leading to tumor eradication ...

The Allen Institute for Immunology as a whole seeks to advance the fundamental understanding of the immune system by employing a full spectrum of -omics tools to understand the molecular pathways and ...

Additionally, Decoy20 triggered short-term increases in multiple key immune system biomarkers (cytokines and chemokines), which play a crucial role in activating the body’s natural defenses ...