On the left, an unactivated RTK receptor (pink ... Signal binding to membrane receptor tyrosine kinases (RTKs) activates an enzyme called a kinase. Learn how kinases initiate a signaling cascade ...

The ERBB receptors are a group of receptor ... looking for tyrosine phosphorylation quantity as a measure of the magnitude or occurrence of activation. They do so because when an RTK becomes ...

At least as important will be what I anticipate is the proof of principle of this important strategy." We are pleased to present the white paper of that group, the International Receptor Tyrosine ...

Conclusion: The tyrosine kinase inhibitors sorafenib and sunitinib offer improved outcomes for patients with mRCC, but they are far short of a cure. Despite the introduction of sorafenib and ...

We are also actively investigating the regulation of Syk tyrosine kinase binding to membrane immune receptors and other signaling proteins. Syk recognizes doubly phosphorylated regions of the receptor ...