APL is a distinct subtype of myeloid leukaemia that in almost 100% of cases is associated with chromosomal translocations involving the PML and retinoic acid receptor α (RARA) loci, leading to ...

St. Jude Children’s Research Hospital scientists resolved the mystery in a new study, showing retinoic acid uses a novel mechanism to kill metastasized neuroblastoma. The drug “hijacks” a normal ...

The researchers showed that BMP signaling makes neuroblastoma cells much more vulnerable to retinoic acid. "Unexpectedly, we ...