Additionally, β-HB activated the AMPK-SIRT1-PGC-1α pathway, with UCP1 and PRDM16 upregulation mediated by β-HB intracellular action and SIRT1 activity. In animal experiments, KE group raised β-HB ...

Department of Chemistry, King’s College London, Britannia House, 7 Trinity Street, London SE1 1DB, U.K.

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Additionally, studies have found that the function of SIRT5 also depends on whether it performs desuccinylation or deacetylation (6). Currently, research on SIRT5 presents many unresolved questions.