In these catabolic conditions the mitochondrial content, morphology and function are greatly affected. The changes of mitochondrial network influence the production of reactive oxygen species (ROS) ...

Moreover, the potential therapeutic strategies and emerging pharmacological interventions, including immune and metabolic modulators, that show promise in preventing or attenuating cardiac fibrosis ...

Understanding how the dystrophin and utrophin protein networks interact with other cellular components may reveal novel characteristics of cytoskeletal function and adaptability. We hypothesized ...

Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22903, United States ...

1 Department of Health, Human Function, and Rehabilitation Sciences, George Washington University, Washington, DC, USA 2 Department of Physical Medicine and Rehabilitation, Johns Hopkins Hospital, ...

35 Table 1. Pathology, Organ Involvement, and Survival in Various Types of Amyloidosis Amyloid deposits in the myocardial interstitium disrupt myocyte function and can lead to diastolic and systolic ...

The muscle fibers are composed of sarcolemma, sarcoplasm, and cell nuclei ... 3 Mitochondria structure is key to its energy production function, with a smooth and permeable outer membrane, an ...

The laminin binding protein dystroglycan plays multiple roles in cell adhesion, signalling and membrane cytoskeleton stability. Perturbation of dystroglycan function underlies several muscular ...

Non-dystrophic myotonias (NDM) are a sub-set of rare (prevalence of 1:100,0004), inherited, myotonic disorders which are caused by mutations within ion channels in the sarcolemma membrane of skeletal ...

Home videos characterising any associated altered motor function (eg, gait, posture) can assist evaluations for an underlying ... Rarely, there are aggregates of mitochondria with ragged-red fibres ...

The liver performs hundreds of vital functions, including converting nutrients from food into energy, filtering toxins from the blood, and producing bile, a key substance in digestion and waste ...