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STING直接与PAR相互作用,促进急性电离辐射介导的DNA损伤后的细胞凋亡
该研究发现,STING(干扰素基因刺激蛋白)在急性电离辐射(IR,ionizing radiation)介导的 DNA 损伤引发的细胞凋亡过程中发挥着关键作用,这一过程不依赖于 I 型干扰素(IFN-I,type I interferon )。研究表明,STING 能与被激活的聚(ADP - 核糖)聚合酶 - 1(PARP1 ...
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