Alzheimer disease, and amyotrophic lateral sclerosis," the Lasker Award grantees wrote in a statement. "Calming the cGAS-cGAMP-STING pathway might therefore provide benefit across a broad span of ...

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...

This previously unknown mechanism for spotting foreign genetic material in the cytoplasm launches antiviral defenses even when the well-known immune mediator STING is absent. Explore how the design ...

We've shown that if you target the cGAS-STING pathway in mouse models of COVID-19, it can reduce the disease severity. One idea now is to interfere with these maladaptive inflammatory states ...

An artist's impression of cGAS-STING pathway response model for micronucleus. Before, cGAS's accumulation in micronuclei was considered to be an indicator of cGAS activation. Now, it was found ...

cGAS was shown to be a member of the nucleotidyltransferase family and to be capable of generating cGAMP in vitro from GTP and ATP in the presence of dsDNA. cGAMP in turn bound to and activated the ...

Their study, “Anti-Herpetic Tau Preserves Neurons vis the cGAS-STING-TBK1 Pathway in Alzheimer’s Disease,” was published in the peer-reviewed journal Cell Reports in early January.

Unlocking the full potential of this molecule’s role in health and disease opens exciting possibilities ... ramped up IRF3 and IFN-β production through STING. The level of IFN-β induction by cGAS was ...

GU ASCO annual meeting featured a kidney cancer trials in progress session and a presentation by Dr. Eric Jonasch discussing a phase 1b/2 study of combination 177Lu girentuximab + cabozantinib and ...