In SLE, there is an imbalance in Th1/Th2 and Th17/Treg[1,2], activation of B cells in CD4+T cell subsets[3], and abnormal activation of CD4+T cells, as well as skin tissue infiltration and Th2/Th17 ...

Gut microbiota composition and sex hormones influence the immune response to methicillin-resistant Staphylococcus aureus gastrointestinal colonization in mice.

After encountering antigen in the periphery and under the influence of the cytokine milieu present, CD4 + T cells can further differentiate into subtypes, including Th1, Th2 and Th17. T cells seem ...

In sum, the proinflammatory contribution of Th17 and Th1 cells, as well as the anti-inflammatory contribution of Th2 and Treg cells have been well recognized in MS/EAE. However, as more Th cell ...

Deciphering the gut biome's, including helminths', influence on human trained immunity will unlock novel immunotherapies harnessing the immune reprogramming potential of their secreted factors and ...

1 State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical ...

在癌症免疫中，Th17 细胞作用存在争议且其向 Tregs 转分化机制不明。研究人员开展关于 NLRP3 在 Th17 细胞中作用的研究，发现 NLRP3 影响 Th17 细胞功能，缺乏 NLRP3 可抑制肿瘤生长。该研究为癌症免疫治疗提供新方向。

The data also highlights its mechanism of action, skewing differentiation to Th1 cells, reducing Th2 and Th17 cells and their downstream cytokines, and promoting a switch to T regulatory cells ...

细胞因子（cytokine, CK）是一类能在细胞间传递信息、具有免疫调节和效应功能的蛋白质或小分子多肽。通过调节免疫细胞的行为， 细胞因子在维持免 疫平衡、抵御传染源和疾病方面发挥着重要作用。细胞因子的主要类型包括：白介素 (IL)：IL-1, IL-2, IL-6, IL-8, IL-10 ...

This antibody has been approved for clinical therapy of patients with IBD.76–79 Mechanistically, this antibody prevents Th1 T-cell priming via IL-12 and simultaneously inhibits perpetuated activation ...

Most often the malignant cells of PTCL express a Th2 phenotype. Corvus Pharmaceuticals is a clinical-stage biopharmaceutical company pioneering the development of ITK inhibition as a new approach to ...