2008; Liu et al., 2017). PMX is an antifolate that simultaneously inhibits the synthesis of both purines and pyrimidines (Shih et al., 1997). PMX and its polyglutamated derivatives inhibit thymidylate ...

Rheumatoid arthritis (RA) is an autoimmune disorder characterized by inflammation and bone erosion. The exact mechanism of RA is still unknown, but various immune cytokines, signaling pathways and ...

We see the seven stones of the Molecular Systems Biology cover as a visual allegory for Aristotle's visionary thought: The whole is greater than the sum of its parts.

The dominant rationale to generate new (and to assess old) anticancer chemotherapeutic agents is to determine their cell-autonomous effects — that is, their capacity to reduce the growth ...