2008; Liu et al., 2017). PMX is an antifolate that simultaneously inhibits the synthesis of both purines and pyrimidines (Shih et al., 1997). PMX and its polyglutamated derivatives inhibit thymidylate ...

Rheumatoid arthritis (RA) is an autoimmune disorder characterized by inflammation and bone erosion. The exact mechanism of RA is still unknown, but various immune cytokines, signaling pathways and ...

Immunotherapy. 2012;4(9):939-945. Potential reasons for the observed improvement in outcomes in vehicle groups include the natural regression of AK lesions, variation in investigator-determined ...

We see the seven stones of the Molecular Systems Biology cover as a visual allegory for Aristotle's visionary thought: The whole is greater than the sum of its parts.

The activation and polarization of T cells play a crucial role in atherosclerosis and dictate athero-inflammation. The epigenetic enzyme EZH2 (enhancer of zeste homolog 2) mediates the H3K27me3 ...

sulfamethoxazole Sulfonamides Folate synthesis inhibition (via acting as competitive inhibitors of dihydropteroate synthetase) Gram-positive cocci Trimethoprim Benzyl-pyrimidine Folate synthesis ...

Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India ...

Institute of Agrobiological Sciences, National Agriculture and Food Research Organization (NARO), 1-2 Owashi, Tsukuba, Ibaraki 305-8634, Japan ...