Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India ...

This manuscript reports a valuable new mechanism of regulation of the glutamine synthetase in the archaeon Methanosarcina mazei and clarifies the direct activation of glutamine synthetase activity by ...

UPP1 facilitates the conversion of 5-FU into its active compounds, thereby enhancing its inhibitory effect on thymidylate synthase. Additionally, data from a Phase I clinical trial (NCT02861300) ...

Gastric cancer (GC) is an exceedingly aggressive disease and ranks as the third leading cause of cancer-related deaths, which poses a huge health burden globally. Chemotherapy is commonly employed ...

Lexicon’s drug is an oral small molecule that blocks Acyl-CoA Synthetase 5, or ACSL5, a metabolic pathway that’s thought to be involved in energy expenditure and fat accumulation.

LX9851 is an oral small molecule that blocks Acyl-CoA Synthetase 5 (ACSL5), an enzyme that plays a key role in a metabolic pathway regulating fat accumulation and energy balance. According to ...

LX9851, discovered and developed by Lexicon, is a potent and selective oral small molecule inhibitor of Acyl-CoA Synthetase 5 (ACSL5) . ACSL5 plays a key role in the metabolic pathway which ...

Novo Nordisk’s stock has remained stable on the news. LX9851 targets Acyl-CoA Synthetase 5 (ACSL5), an enzyme involved in fat metabolism and energy balance. Preclinical data presented at Obesity Week ...

Novo Nordisk’s stock has remained stable on the news. LX9851 targets Acyl-CoA Synthetase 5 (ACSL5), an enzyme involved in fat metabolism and energy balance. Preclinical data presented at Obesity ...

The study reveals that hepatocytes producing a protein known as glutamine synthetase, which regulates glutamate levels, play a key role in regeneration. MORE PROGRESS: Tumor-Destroying Sound Waves ...