This active repressor can bind to a region near the promoter called an operator (yellow) and thus interfere with RNA polymerase binding to the promoter, effectively preventing transcription.

"This surprising discovery points to a small but crucial feature of the transcription factors: their START domain," a lipid-binding region within the TFs, which the researchers liken to a foreman ...

Torsional stress in chromatin plays a fundamental role in cellular functions, influencing key processes such as transcription, replication, and chromatin organization. Transcription and other ...

This precise transcribing of genes is handled by proteins known as transcription factors, which bind to the regulatory DNA, thereby generating instructions for the coding region. A fly's body has ...

The lab of Dr. Mark Magnuson, Louise B. McGavock Professor and professor of molecular physiology and biophysics at Vanderbilt ...