Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis of tumor cells but not most normal cells. Its roles in normal nontransformed tissues are not clear.

Background and Aims: Lung cancer is a leading cause of cancer mortality worldwide and is associated with the release of tumour necrosis factor-α (TNF-α), subsequent cellular apoptosis ... Gardner, R.

DelveInsight’s, “Metastatic Colorectal Cancer Pipeline Insight 2025” report provides comprehensive insights about 150+ ...

(Shattuck) (NASDAQ: STTK), a biotechnology company pioneering the development of novel therapeutics targeting tumor necrosis factor (TNF) superfamily receptors for the treatment of patients with ...

Clustering of type-II tumor necrosis factor receptors (TNFRs) is required to induce intracellular signaling. Current methods for receptor clustering lack precise control over ligand valency and ...

such as tumor necrosis factor-beta (TNF-β). Calcitrol induces cell death by inhibiting anti-apoptotic proteins and promoting the expression of pro-apoptotic proteins. Calcitriol also limits the ...

Methods 127 erosions were identified in metacarpophalangeal joints 2–4 of the right hands of 30 RA patients treated with tumour necrosis factor inhibitors (TNFi) and 21 sex, age and disease ...

The tumor microenvironment (TME) is a highly complex and continuous evolving ecosystem, consisting of a diverse array of cellular and non-cellular components. Among these, benign non-immune cells, ...

The pramiry materials and methods used in the experiments were listed below, and the flow chart of the whole study was shown in Figure 1. Peripheral venous blood samples from the elbow vein were ...

one might expect that CD200 knockout mice would be susceptible to SIRS when injected with tumor necrosis factor (TNF)-inducing microbes or their products. SIRS was apparently not observed during ...