MTX decreases TYMS activity by inhibition and decreasing the access to tetrahydrofolate (THF) cofactors (1). The most common genetic variant of the TYMS gene consists of a 28 bp tandem repeat ...

These include mutations in the DPYD, ERCC1, MTHFR, TYMS, and XRCC1 genes, which may influence the patient’s response to chemotherapy and overall prognosis. This gene encodes a protein involved in the ...

The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...

Gene expression is the generation of a functional gene product from the information encoded by a gene, through the processes of transcription and translation. Gene products are often proteins ...

Gene therapy involves the introduction of new genes into cells, to restore or add gene expression, for the purpose of treating disease. Most commonly a mutated gene is replaced with DNA encoding a ...

Summarizing these molecular mechanisms, it can be seen that the gene polymorphisms of MTX transporters, as well as those of the enzymes in the folate and adenosine pathways, are the focus of ...

The company, which secured $200 million from investors in a private funding deal last week, learned Tuesday of a serious side effect experienced by one participant on a high dose of its Rett therapy.

The patients included in this study were recruited consecutively from January 1999 to April 2012 at the Hospital de la Santa Creu i Sant Pau (Barcelona, Spain) and Hospital Moises Broggi ...

A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

TYMS, and ZWINT. Profiling the Cell-Cell Communication in Healthy and Periodontitis Samples The cell-cell communication was measured by quantification of ligand-receptor pairs among different cell ...

Identification of gene subset commonly enriched in cultured CTC of the present study and previously ... In contrast, no difference was observed for the expression of TYMS (involved in 5-FU metabolism) ...