The results revealed that p53 siRNA significantly reduced the expression of HG- and IL-1β-induced xCT and GSH (68). Other molecules, such as TRIM46, are also involved in regulating lipid Peroxidation ...

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Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4), which is considered ...

Hepatocellular carcinoma (HCC) mostly occurs in the background of liver fibrosis, and activated hepatic stellate cells (HSCs) exist in HCC tissues and adjacent tissues. HSC activation is involved ...