In our previous reports, we have demonstrated that the plant ATG5 plays an essential role in activating autophagy in rice stripe virus (RSV)-infected plants. We also showed that eIF4A, a negative ...

The eIF4 factors include mRNA 5′ cap-binding protein eIF4E, ATP-dependent RNA helicase eIF4A, and scaffold protein eIF4G, which anchors eIF4A and eIF4E. Another eIF4 factor, eIF4B, stimulates the RNA ...

Alterations in the expression and activity of specific translation factors, and the uncoupling of translational regulation from inhibition by tumour cell stresses, such as hypoxia and nutrient ...

Department of Pharmacology, Physiology & Biophysics, Boston University, Boston, Massachusetts 02215, United States ...

The second pathogenic mechanism involves a gain-of-function (GOF) due to the formation of toxic RNA foci from repeat expansion transcripts (reviewed by McEachin et al., 2020b). RNA foci are a ...

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Im zweiten Teil des Vortrags wurde auf die Bindung des Naturstoffs Sylvestrol an den Translationsinitiation Faktor-4A (eIF4A) eingegangen. Diese Bindung, die spezifisch die Virusvermehrung in ...