Panning for CTAP. By sifting through the genome of K562 myeloid progenitor cancer cells, Muhar and colleagues identified genes that mediate the breakdown of proteins (green) carrying C-terminal amides ...

The U.S. Food and Drug Administration approved Eisai and Biogen’s application for IV maintenance dosing of lecanemab on January 27. Previously, the label called for biweekly IV dosing. The new ...

For each structural strain of tau fibrils, they identified amino acids without which the strain cannot form its signature ...

The X contains more genes related to brain function than does any other chromosome. “The X chromosome may be a treasure trove of genes that influence cognition, and these could be therapeutic targets, ...

The National Alzheimer’s Coordinating Center unites the collections of the neuropathology cores at 27 NIA-funded AD Research Centers into a single database. It contains records on 13,000 brains, 3,000 ...

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SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.

Unknown. Multiple in silico algorithms yielded conflicting results.

The center unites the collections of the neuropathology cores at 27 NIA-funded AD Research Centers into a single database. It contains records on 13,000 brains, 3,000 of them with extensive clinical ...

Unknown; predicted pathogenic in silico (CADD>20).

Early onset familial Alzheimer disease (eFAD) is hereditary and marked by Alzheimer disease symptoms that appear at an unusually early age. Symptoms can start in a person's thirties, forties, and ...

Lactylation is a reversible, covalent, post-translational modification of proteins. It happens exclusively on lysine residues, where it influences protein structure, stability, localization, and ...