An AST/ALT ratio higher than 2:1 (where the AST is more than twice as high as the ALT) is a common sign of alcoholic liver disease. Results of LDH levels are usually used to check for tissue damage.

Continued hepatic assaults, including dietary, alcoholic ... such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) can be the first indicators of a compromised liver.