“It is no use asking for the impossible, such as, say, the exact wiring diagram for a cubic millimeter of brain tissue and the way all its neurons are firing,” Crick wrote in Scientific America ...

Hormones are small molecules or peptides that act in signalling between one cell or cell set and another. They are generally involved in high-level processes of an organism such as growth ...

Paraquat (1,1’-dimethyl-4,4’-bipyridyl dichloride) is a non-selective herbicide still widely used in agricultural crops in vast regions around the world for weed control (Zobiole et al. 2018) and also ...

Unhas Fly Research Group, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar 90245, Indonesia Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar ...

Perspectives from Keith Churchwell, MD, FAHA Keith C. Ferdinand, MD CHICAGO — The investigational aldosterone synthase inhibitor lorundrostat effectively lowered 24-hour BP for adults with well ...

Across participants in general, the vast majority were on renin-angiotensin-aldosterone system inhibitors and beta-blockers; around 60% were on SGLT2 inhibitors. Over follow-up, investigators ...

Lorundrostat is in a new class of blood pressure medications called aldosterone synthase inhibitors (ASIs). Several ASIs are currently in development and are designed to work by disrupting the ...

The use of a therapy which targets aldosterone production is promising as a new treatment in resistant hypertension if these data are confirmed by subsequent phase 3 clinical trials. Presented by Dr.

Lorundrostat is an aldosterone synthase inhibitor that reduces aldosterone levels by inhibiting CYP11B2, the enzyme responsible for its production. A previous phase 3 study, Launch-HTN ...