This work presents valuable data demonstrating that a camelid single-domain antibody can selectively inhibit a key glycolytic enzyme in trypanosomes via an allosteric mechanism. The claim that this ...

Department of Biomedical Chemistry, Faculty of Chemistry, University of Gdańsk, Gdańsk 80-308, Poland ...

The authors identified nanobodies that were specific for the trypanosomal enzyme pyruvate kinase in previous work seeking diagnostic tools. They have shown that a site involved in the allosteric ...

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart – an important process for maintaining heart health. In the study ...

School of Environment and Energy Engineering, Gwangju Institute of Science and Technology (GIST), 123 Cheomdan-gwagiro, Buk-gu, Gwangju 61005, Republic of Korea Research Center for Innovative Energy ...

Tryptophan is an essential amino acid, which is not only a building block for protein synthesis, but also a precursor for the biosynthesis of co-enzymes and neuromodulators ... The hormones released ...

A superfamily of approximately 100 ubiquitin-specific proteases, called deubiquitylating enzymes, deubiquitinases ... however this is not always essential for activity, as exemplified in the ...

A new study has identified an enzyme that plays an important role ... for which USP5 is essential, for the first time. We assume that inhibiting the loss of USP5 or therapeutically increasing ...

A conserved intracellular loop 1 (ICL1) bridges cytosolic regulatory domains and the ion translocation path via simultaneous interactions with the NTD and intracellular gate region. The NKCC1 CTD ...

Several proteins that have an essential role in autophagy have a direct ... Lenardo and co-workers showed that catalase, a key enzyme of the cellular antioxidant defence mechanism, was selectively ...

Meiosis is a type of specialized cell division through which germ cells reduce their chromosome composition from diploid to haploid. Faithful completion of the first meiosis is therefore a critical ...

LPL is an enzyme essential to fat metabolism. After a meal, the small intestine processes dietary fats and packages them into chylomicrons. Chylomicrons are vehicles that carry triglycerides ...