The effects of caspases on cellular substrates bring about the biochemical and morphological features of apoptosis (Fig. 1). Caspase proenzymes ... polymerase (PARP) and degradation of ICAD ...

Abstract: As an inhibitor of poly(ADP-ribose) polymerase (PARP), nicotinamide has a restraining effect on apoptosis at certain low concentrations. In our present study, apoptosis induced by high ...

Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung 407219, Taiwan R.O.C. Department of Physical Therapy, Hung Kuang ...

Taken together, these results demonstrate that the PAC-1/sunitinib combination enhances cell death by increasing caspase-dependent apoptosis and inhibiting autophagy in BON cells. PAC-1/Sunitinib ...

During IRI, ADP-ribosylation plays a central role in regulating apoptosis, inflammatory responses, and mitochondrial function. Poly(ADP-ribose) polymerase-1 (PARP-1), a key enzyme in this process, is ...

胰腺癌治疗困难，KRASG12D突变常见。研究人员合成金纳米粒子 - 白藜芦醇复合物（GRs）研究其抗癌活性。结果显示 GRs 能抑制 AsPC-1 细胞活力、诱导凋亡。这为胰腺癌治疗提供新方向。

自1979年被发现以来，p53蛋白已成为了研究最为广泛和深入的肿瘤抑制因子之一。作为转录因子，p53调控众多下游信号通路，诱导细胞周期停滞、细胞凋亡和衰老是其最“经典”的功能，也被认为是其清除受损细胞、防止癌细胞发生的主要手段。学术经纬相关阅读：人类 ...

根据 Insight 数据库年报销售数据板块，奥拉帕利是最畅销的 PARP 抑制剂，2024 年销售额为 30.72 亿美元。他拉唑帕利去年收入了 1.17 亿美元。

This can often bring about high blood glucose levels. However, there is more than one type of diabetes. The most common are type 1 and type 2 diabetes. Type 1 diabetes is an autoimmune condition in ...

当细胞受到氧化应激时，NRF2 会被激活，进而启动一系列抗氧化基因的转录程序，生成具有抗氧化功能的蛋白质，比如谷胱甘肽 S - 转移酶（Glutathione S - transferase，GST）、血红素加氧酶 - 1（Heme Oxygenase ... 细胞凋亡的基本过程 细胞凋亡（Apoptosis）是一种程序性 ...