Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, ...

AXL is a receptor tyrosine kinase that plays a crucial role in various cellular processes, including cell survival, proliferation, and migration. Dysregulation of AXL signaling has been implicated in ...

The cannabidiol (CBD) world can feel huge and complicated, but products like CBD gummies make it more approachable for some folks. CBD gummies are easy to dose, portable, and discreet. They also ...

Dopaminergic neuron dysfunction has been implicated in multiple neurological and psychiatric disorders. SELENOT is a selenocysteine-containing protein of the ER membrane with antioxidant and ...

Here we studied the role of Fms-like tyrosine kinase 3 ligand (Flt3L) signalling in the pathogenesis of collagen-induced arthritis (CIA). Methods CIA was induced in mice lacking Flt3L (Flt3L −/−) and ...

Orpathys blocks atypical activation of the MET receptor tyrosine kinase pathway that occurs because of mutations (such as exon 14 skipping alterations or other point mutations), gene amplification or ...

Request permissions for this article. Eppley Institute for Research in Cancer and Allied DiseasesUniversity of Nebraska Medical Center Omaha NE USA Fred & Pamela Buffett Cancer CenterUniversity of ...

This crystal structure of nearly full-length human cGMP-dependent protein kinase Iβ (PKG Iβ) provides convincing new insights into how in the absence of cGMP the activity of the catalytic domain is ...

fusion protein containing the extracellular domain of TrkB fused to Fc domain; V2R, vasopressin receptor; RT-qPCR, quantitative reverse transcriptionPCR; VGAT, vesicular GABA transporter; GABA, ...