We previously described methods for the construction of tissue microarrays (TMAs) and immunohistochemistry (IHC) (24). Briefly, antihuman rabbit monoclonal antibodies for FOXP3 (1:50; #98377S, CST, ...

I-DXd targets B7-H3, a protein overexpressed on the surface of a wide variety of cancer cells that binds to the CD28 family of receptors, which includes PD-1, targeted by MSD's widely used ...

Immunologic checkpoint blockade with antibodies against the programmed cell death protein-1 (PD-1) or its ligand (PD-L1) is an effective method for reversing cancer immunosuppression and thereby ...

Introduction: Mounting evidence has revealed that the interactions and dynamic alterations among immune cells are critical in shaping the tumor microenvironment and ultimately map onto heterogeneous ...

Recent advances using transgenic animals or exogenous complement inhibitors have demonstrated prevention of hyperacute rejection of vascularized organs, but not graft loss due to acute vascular ...

Objective The PD-1 axis promotes protection against autoimmunity. Immune checkpoint (IC) molecules performance in anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) remains unknown. This ...