This article was originally published with the title “ The Nucleotide Sequence of a Nucleic Acid ” in Scientific American Magazine Vol. 214 No. 2 (February 1966), p. 30 doi:10.1038 ...

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In 1958, Francis Crick's sequence hypothesis finally provided an answer to the question: what is a gene? Why is this definition now considered overly simplistic? Roberts and Sharp also noted that ...