在临床和生物医学研究中，原位监测活细胞中相关 DNA 修复酶活性意义重大。研究人员构建双模式逻辑金纳米耀斑策略，对细胞内 APE1 和 FEN1 进行 OR/AND 逻辑成像。体外实验显示其生物相容性高，该策略在疾病诊断等方面有广阔应用前景。

DNA repair is crucial for human well-being. This marcromolecule makes up our chromosomes and is present in our body cells. It carries a detailed code that enables us to make the proteins we need for ...

Using data from Genomics England’s 100,000 Genomes Project, the team developed an algorithm that can identify tumours with specific DNA repair faults that make them more responsive to treatment. The ...

DNA repair mechanisms are crucial for the survival and growth of cells. Through a comprehensive analysis, a research team at ETH Zurich has identified numerous redundancies between the genes involved ...

Scientists have long known that more than 500 genes (out of approximately 20,000 human protein-coding genes) are crucial for DNA repair. By comprehensively analyzing the interactions of these ...

Complex DNA-breakage events such as chromosomal shattering, followed by genome rearrangement, DNA repair, and end-to-end ... to hundreds of thousands of DNA base pairs, offers the means to ...

Scientists have long known that more than 500 genes (out of approximately 20,000 human protein-coding genes) are crucial for DNA repair. By comprehensively analysing the interactions of these ...

线粒体作为细胞的“能量工厂”，其基因组突变与母系遗传病、衰老及多种疾病密切相关。在已报道的疾病相关碱基替换中，超过40%的替换为G-to-A/C-to-T突变，这些突变可以通过A-to-G碱基编辑恢复。但是目前可对线粒体基因组进行A-to-G碱基编辑 ...

In this light, Pakistan’s army strengthening its base in Balochistan’s Shamsi is also significant and points to instability in the region. The Kotli air-base is situated in the area under the army’s 3 ...

Research indicates that most organisms have multiple ligases dedicated to distinct DNA repair pathways, including nucleotide excision repair, base excision repair, and nonhomologous end joining for ...

Dallas-based biotech company Colossal has announced the birth of three pups bearing the DNA signatures of dire wolves, an iconic predator last seen roaming North America over 10,000 years ago. With ...