Johns Hopkins University School of Medicine researchers have discovered a dual regulatory mechanism safeguarding ...

Parkin ubiquitinates DRP1, leading to the proteasomal degradation of DRP1 and inhibiting mitochondrial ... and MICU. (3) LRRK2 blocks PERK mediated phosphorylation and activation of Parkin and MULAN, ...

Mitochondrial fission is regulated primarily by Drp1, which is typically located in the cytoplasm. The activity of Drp1 is regulated by translocation as well as post-translational modifications, such ...

Mitochondrial fission is mediated by recruitment of Drp1 and their anchor on the outer mitochondrial membrane. Post-translational modifications of Drp1, especially phosphorylation, affect their ...

Following an initial burst of fission, a new steady state of neurotrophin-dependent mitochondria length is established. Mek-Erk controls the activity of the fission mediator Drp1 GTPase, while PI3K ...