Johns Hopkins University School of Medicine researchers have discovered a dual regulatory mechanism safeguarding ...

Specifically, Drp1 is genetically required for border cell migration, and Drp1-mediated mitochondrial fission promotes formation of leading protrusion, likely through its regulation of ATP levels.

Drp1, Fis, and Mff are the major proteins involved in mitochondrial fission ... The first one, uses transgenic mice with knock-in mutations on Bcl2 phosphorylation sites that cannot trigger autophagy ...

Mitochondrial fission is regulated primarily by Drp1, which is typically located in the cytoplasm. The activity of Drp1 is regulated by translocation as well as post-translational modifications, such ...