Doxorubicin (DOX) has received widespread attention as a broad-spectrum antitumor drug. However, it has been a recognized challenge that long-term DOX injections can lead to severe cardiotoxicity.

Doxorubicin is a type of anthracycline chemotherapy drug used to treat certain types of solid tumors and blood cancers. It has a number of side effects, some more serious than others. Experts ...

Department of General Surgery, Tianjin Union Medical Center, Tianjin 300122, P. R. China These authors contributed equally to this work.

Doxorubicin and ifosfamide are chemotherapy drugs. They are sometimes used in combination to treat soft tissue sarcomas. It is best to read this information with our general information about ...

Under chronic conditions, NLRP3 inflammasome acts as instigator of pathological inflammation causing inflammation-induced carcinogenesis. Despite killing the cancer cells and being primary treatment ...

Chemotherapy with an anthracycline is an integral part of curative therapy but resistance remains a clinical problem. Cellular senescence is a terminal cell fate that has been observed in models of ...

SAN DIEGO, April 01, 2025 (GLOBE NEWSWIRE) -- Ventyx Biosciences, Inc. (Nasdaq: VTYX) (“Ventyx”, “Company”), a clinical-stage biopharmaceutical company ...

When TBK1 is lost or mutated, it fails to perform its protective role, allowing two major cell death pathways, RIPK1 and NLRP3, to become overactive. This overactivity leads to excessive cell ...

The new SAB members have made vital discoveries in understanding the role of the NLRP3 inflammasome in neuro- and systemic inflammation, and are at the forefront of clinical development in ...