1). This mutation therefore ‘rewires’ the substrate specificity of an E3 ligase to induce aberrant degradation of proteins that are required for normal cellular function. Control of human ...

A disrupted protein degradation process in heart muscle cells can lead to a range of severe heart diseases. In the case of dilated cardiomyopathy, a pathological enlargement of the heart chambers ...

By getting producing cells ‘addicted’ to production, the start-up aims to vastly improve production efficiency in a range of fermentation-based industries, including alternative proteins. When ...

PROteolysis TArgeting Chimeras (PROTACs) are small molecules that induce target protein degradation via the ubiquitin-proteasome system. PROTACs recruit the target protein and E3 ligase; a critical ...

Edited by: Thomas W. Durso and Karen Young Kreeger M. Hochstrasser, "Ubiquitin, proteasomes, and the regulation of intracellular protein degradation," Current Opinion in Cell Biology, 7:215-23, 1995. ...

German fermentation specialist Formo has received €35M in venture debt from the EU’s lending arm to scale up its dairy and egg alternatives and pursue regulatory approval for its animal-free casein ...

However, their complex chemical structure and the high presence of sulfate residues in some of them could limit their fermentation by the gut microbiota (GM) and eventually stimulate the formation of ...

Players need to find the right ingredients and the right blend to develop effective plant-based formulations, particularly in terms of taste and nutritional profile. Yeast protein, such as Springer ...