Joint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130021, P. R. China Department of ...

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China ...

Protein concentration was determined using a BCA assay kit. Approximately 30 µg of proteins were separated by SDS-PAGE ... ab32503), Anti-FACL4 (Abcam, ab205197), Anti-GPX4 (Abcam, ab125066), ...

在此，研究揭示了 S - 棕榈酰化（S-palmitoylation）通过谷胱甘肽过氧化物酶 4（Glutathione peroxidase 4，GPX4）对铁死亡（ferroptosis）的关键调控作用，GPX4 是一种减轻脂质过氧化的关键酶。研究人员鉴定出，在多种肿瘤中高表达的 S - 酰基转移酶 —— 含锌指 DHHC 结构域 ...

1 Xuzhou Clinical College of Xuzhou Medical University, Division of Cardiology, Xuzhou Central Hospital, Xuzhou, Jiangsu, China 2 Xuzhou Institute of Cardiovascular Disease, Xuzhou, Jiangsu, China ...

DIM induced ferroptosis in NSCLC cells; increased cellular Fe 2+, ROS (reactive oxygen species), and MDA; decreased cellular GSH, AHR, NRF2, and GPX4; and disrupted the mitochondrial membrane ...

The Saluggia, Italy-based firm said that the Simplexa C. auris Direct kit is a real-time PCR assay that is used for the detection of DNA from six clades of the fungal pathogen in a composite ...

Myristicin regulates proliferation and apoptosis in oxidized low-density lipoprotein-stimulated human vascular smooth muscle cells and human umbilical vein endothelial cells by regulating the PI3K ...

3月11日，上海同济大学研究团队在期刊《Clinical And Translational Medicine》上发表了研究论文，题为“p53 inhibits OTUD5 transcription to promote GPX4 degradation and ...

为解决三阴性乳腺癌（TNBC）治疗难题，美国北卡罗来纳大学教堂山分校研究人员开展 TNBC 与氧化应激关系研究，发现 GPX4 与 TNBC 进展及治疗反应相关，为治疗提供新靶点。 在女性健康的 “敌人” 中，乳腺癌一直占据着重要位置，尤其是三阴性乳腺癌（TNBC ...