This study presents a useful finding that targeting amino acid metabolism can overcome Trastuzumab resistance in HER2+ breast cancer. The evidence supporting the claims of the authors is solid and the ...

Figure 3 The mechanism of the antioxidant system in ferroptosis. The primary antioxidant system is the GSH/GPX4 system that reduces PUFAs-OOH to non-cytotoxic PUFAs-OH, while GSH is oxidized to GSSG.

In the fourth cohort, the deliberate propulsion of lipid peroxidation precipitates the unfolding of cellular ferroptosis. There are primarily three mechanisms for inhibiting iron-dependent cell death.

a Department of Surgery, University of Heidelberg, Heidelberg, Germany, b Department of Immunochemistry, German Cancer Research Center, Heidelberg, Germany Dr B Sido, Department of Surgery, University ...

高度近视在全球的患病率呈上升趋势，已成为严峻的健康挑战。高度近视性白内障作为高度近视最常见的并发症，发病年龄比年龄相关性白内障更早，严重影响患者工作期间的生活质量。由于晶状体核通常较硬，HMC 的手术干预难度较大，因此深入了解其发病机制对开发潜在治疗方法至关重要。

Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China CAS Key Laboratory for ...

Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4), which is considered ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.