血管内皮铁死亡与动脉粥样硬化密切相关，达格列净（DAPA）虽能延缓动脉粥样硬化进展，但机制不明。研究人员构建细胞和动物模型研究发现，DAPA 激活 RAP1B/NRF2/GPX4 信号通路、促进线粒体生物发生，减轻铁死亡，为防治动脉粥样硬化提供新依据。

Selenium and GSH are not merely endogenous and indispensable key constituents in the cellular orchestration of ferroptosis, a fundamentally crucial biological process, but also operate as obligatory ...

前列腺癌严重威胁男性健康，现有治疗手段存在局限。研究人员聚焦分支链氨基酸（BCAAs）及 BCAT2 在前列腺癌中的作用。发现 BCAT2 高表达与预后不良相关，其通过与 PCBP1 互作调节 PI3K/AKT 通路，影响细胞进程。该研究为前列腺癌诊疗提供新靶点和思路。

2018; Panizo et al., 2021). Hence, it is crucial to investigate the mechanisms driving EMT to uncover novel strategies for CKD. Ferroptosis is a newly form of cell death controlled by the lipid-repair ...

Joint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130021, P. R. China Department of ...

Within the core program, TFE3 fusions directly regulate genes involved in ferroptosis resistance and oxidative phosphorylation metabolism (OxPhos). Consequently, human tRCC tumors display high OxPhos ...

Glutathione (GSH) is an antioxidant naturally produced by the liver and central nervous system. It is also available as a supplement. GSH is thought to help break down toxins and free radicals ...