Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China CAS Key Laboratory for ...

Martin-Sanchez confirmed the presence of the characteristics of ferroptosis in folate-induced mouse AKI models, which are lipid peroxidation and downregulation of GSH (Martin-Sanchez et al ... GR or ...

Erastin (ER), a ferroptosis inducer, kills tumor cells by generating and accumulating reactive oxygen species (ROS) within the cell, resulting in an iron-dependent oxidative damage-mediated ...

From the GO analysis, we screened the upregulated differentially expressed genes and identified key pathways, including mitophagy, autophagy, ferroptosis, apoptosis, nonalcoholic fatty liver disease ...

However, the liver's robust antioxidant defenses, including glutathione (GSH) and vitamin E, question the widespread applicability of ferroptosis as a primary mode of cell death in DILI.