关键突变实验证实W73 2.60 和Y24 1.39 对拮抗剂活性至关重要。 "逐步质子感应"模型提出：在初始激活阶段（pH7.5），仅H269 7.36 被质子化；随着pH降低，ECL2构象变化使H165 ECL2 加入感应网络，实现完全激活。这种"分步启动"机制解释了GPCRs对pH变化的梯度响应。

"Navkar Mahamantra embodies humility, peace and universal harmony. Delighted to take part in the Navkar Mahamantra Divas programme," the Prime Minister wrote on X. Navkar Mahamantra embodies ...

At Stockholm’s spherical Avicii Arena, a massive new internal roof of folding acoustic panels enables the venue to rapidly transform in response to its music and sports events schedule The new 80m x ...

As promised, Harmony Road repairs will continue into a new phase, causing some lane closures for the next five weeks. The city of Fort Collins recommends taking alternate routes to avoid the ...

Paul Simon has defied odds by kicking off his 2025 North American tour, following a return from retirement and struggles with his hearing. The live shows kicked off in New Orleans on Friday night ...

In this picturesque atmosphere of nature’s varied splendor, Guyana’s population of six races/ethnicities, interact daily with civility, and an ever-increasing harmony that critics of the current ...

Acoustic guitars aren’t very metal. That is, until you hear the intro of Metallica’s Fade to Black, or till Black Sabbath’s Planet Caravan sparks a compulsion to turn the overdrive down and jam the ...

The show, dubbed An Acoustic Evening with Jessie J Live, is set to take place at Union Chapel next month, on May 20. Tickets go on sale tomorrow (April 4) at 10am local time – you can get yours ...

If there’s one thing you can do to take your songwriting to the next level, it’s getting to grips with new chords. Use our acoustic guitar chord charts - from basic open chords to the daddy of altered ...

Add a description, image, and links to the toon-boom-harmony topic page so that developers can more easily learn about it.