but the presence of multiple inhibitors is likely to be important in balancing the NF-κB activation and specific gene regulation. Activator protein 1 (AP-1) is an important transcription factor ...

As a transcription factor, the heterodimer of RUNX3 and a beta subunit form a complex that binds ... and apoptosis in AML cells. Runx3 Knockdown Inhibits the Expression Levels of Genes Involved in DNA ...

A research team has identified the transcription factor Lhx2 (LIM homeobox protein 2) as a key regulator in hepatic stellate cells. Lhx2 was found to simultaneously promote liver regeneration and ...

The transcription factor nuclear factor-κB (NF-κB) family has a central regulatory role in the expression of many genes related to immune responses, inflammation, cell survival and cancer. Previous ...

Through the activation and repression of the target genes, transcription factors (TFs) determine the fate of cells within tissues, organs and organisms, controlling the development. Most TFs act ...

In this study, the role of the ductal transcription factors hepatocyte nuclear factor 6 (HNF6 ... 0.1% SDS) complemented with protease inhibitors (Sigma). For western blot analysis, protein extracts ...

In this video, Stephen M. Ansell, MD, PhD professor of medicine, chair of the division of hematology, co-leader of the hematological malignancies program, and interim chair of the department of ...

One conceptual answer to this question is by an ancient transcription factor regulating ciliary gene expression in both unicellular and multicellular organisms, but examples of such transcription ...

INT-747 significantly decreases tumour necrosis factor α secretion in activated human peripheral blood mononuclear cells ... and reduced goblet cell loss. Furthermore, FXR activation inhibits ...

Casdatifan targets a transcription factor that binds with other proteins to switch off the body’s anti-inflammatory ...

In this video, Aruna Padmanabhan, MD, discusses the evaluation of PI3K inhibitor combinations as first-line treatment for patients with metastatic breast cancer.