The findings suggest that lipid metabolism may play a central role in maintaining a healthy immune system as we age. The researchers analyzed gene and protein expression, along with lipid profiles, in ...

The accumulation of dysfunctional giant mitochondria is a hallmark of aged cardiomyocytes. This study investigated the core mechanism underlying this phenomenon, focusing on the disruption of ...

The Farese & Walther laboratory investigates cellular lipid and energy metabolism, in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets. More broadly ...

A healthy liver controls lipid metabolism by oxidising fatty acids and secreting bile for fat digestion. In hepatic steatosis, hepatocytes accumulate excess triglycerides, which impede the liver's ...

The crosstalk between bile acid (BA) metabolism and the Hippo pathway plays a role in pathogenesis of liver diseases. Here the authors show that the transcriptional coactivator YAP exerts a ...