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揭示 MAPT 突变致神经退行性疾病新机制:V337M 和 R406W 突变 tau 丝结构 ...
研究人员针对额颞叶痴呆(FTD)等疾病,解析 MAPT 突变 V337M 和 R406W 的 tau 丝结构,发现其呈阿尔茨海默折叠。 在神经退行性疾病的研究领域,额颞叶痴呆(FTD)和阿尔茨海默病(AD)是最常见的早发性痴呆类型。FTD 以行为改变为首发症状,随后才出现认知障碍 ...
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