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Key form of tau protein identified for understanding and treating Alzheimer's diseaseThe study is published in the Alzheimer's & Dementia journal under the title "The TAU isoform 1N4R confers vulnerability of ...
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Genetically modified mice hint at tau hyperphosphorylation's early role in neurodegenerative diseasesWe have developed a series of targeted mice expressing frontotemporal-dementia-causing mutations in the humanized MAPT gene to investigate the earliest stages of tauopathy." Tau ...
Scientists have identified the 1N4R tau isoform as a key driver of Alzheimer’s disease, paving the way for potential new ...
Scientists from the University of Cologne identified the 1N4R tau isoform as a key contributor to neuronal dysfunction in ...
Frontotemporal dementias can be caused by mutations in MAPT, which encodes the protein tau; the mutant protein forms harmful aggregates in the brain. Cryo-electron microscopy of tau filaments from ...
The study was published in the Alzheimer’s & Dementia journal under the title “The TAU isoform 1N4R confers vulnerability of MAPT knockout human iPSC-derived neurons to amyloid beta and ...
The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC-derived neurons to amyloid beta and phosphorylated tau-induced neuronal dysfunction, Alzheimer's & Dementia (2025).
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