41 The efficacy of a variety of cell types, e.g. MSCs, in orchestrating a program of healing in the injured heart suggests a possible mechanism of cardiac repair that is broader than simple ...

Bone-marrow-derived multipotent progenitor stromal cells — or mesenchymal stem cells (MSCs ... This Review discusses the targets and mechanisms of MSC-mediated immunomodulation and the ...

Inflammatory eye diseases can be challenging to treat, with medications like corticosteroids causing unwanted complications such as glaucoma. However, a study led by researchers from Fujita Health ...

We were the first lupus organization in the U.S. to support stromal cell research. In partnership with the National Institute of Allergy and Infectious Diseases, we committed nearly $4 million over ...

Graft-versus-host disease (GVHD) is a common and severe complication that occurs after stem cell transplantation, where the donor's immune cells attack the recipient's tissues.

"This first mesenchymal stromal cell therapy approval demonstrates the ... According to its proposed mechanism of action, remestemcel-L reduces systemic inflammation by way of immunomodulatory ...

NEW YORK, Jan. 16, 2025 /PRNewswire/ -- The Food and Drug Administration (FDA) approved the first mesenchymal stromal cell (MSC) therapy, RYONCIL®, indicated for steroid-refractory acute graft ...

Therefore, it is critical further to investigate the mechanisms of ... and the migration of stromal cells like CAFs and TAMs. Periostin also enhanced mesenchymal stem cell and macrophage migration ...

At its third attempt, Mesoblast has secured FDA approval for Ryoncil as a treatment for children with graft-versus-host disease, the first-ever approval for a mesenchymal stromal cell (MSC ...

Our research focuses on the tumor-permissive molecular mechanisms underlying cancer-associated fibroblast function as well as immune suppression, and how these stromal mechanisms affect cell fate and ...