Tau hyperphosphorylation contributes to microtubule destabilization ... These kinases are also associated with β-amyloid precursor protein (APP) processing and β-amyloid-induced neurotoxicity.

in regulating the function of the microtubule-associated protein Tau. This discovery deepens our understanding of dopamine's physiological and pathological roles in the human brain. The research ...

BIIB080 is an investigational antisense oligonucleotide therapy that targets microtubule-associated protein tau mRNA preventing the production of the disease-causing protein. The Fast Track ...

Researchers investigate tauopathy mechanisms and turn to tau detection methods to help improve health care outcomes and lower the economic burden of these diseases. The microtubule-associated protein ...

BIIB080 is an investigational antisense oligonucleotide (ASO) therapy designed to target microtubule-associated protein tau (MAPT) mRNA to reduce the production of tau protein. Abnormal ...

More information: Naoto Watamura et al, In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds, Nature Neuroscience (2024 ...

We are encouraged by the FDA’s Fast Track designation for BIIB080, which highlights the urgent need for innovative treatments targeting tau pathology in Alzheimer’s disease,” said Priya Singhal, M.D., ...