A mitochondrial network consists of a complex, branched system of connected mitochondria (Figure 1). Some modern textbooks still depict mitochondria inaccurately as small, static ovoid organelles ...

Drug-induced mitochondrial dysfunction has been linked to compound attrition, organ toxicity, black-box warnings and market withdrawals, therefore it is important to identify mitochondrial toxicity ...

As a team we are dedicated to improve the life of patients with mitochondrial disease by understanding the mechanisms underlying these maladies that have no treatment option to date.

Mitochondrial function depends on the intricate shape, membrane ultrastructure, and dynamics of the organelle. Abnormalities in these aspects can lead to organelle dysfunction and ultimately result in ...

The study 'Enhanced mitochondrial fusion during a critical ... process new neurons undergo while integrating into the network ...

The presence of mitochondrial DNA with deletions—the ... (IIBB-CSIC); both linked to the Center for Biomedical Research Network in Neurodegenerative Diseases (CIBERNED). The first author of ...

Prince Robert described the disease as "a genetic mitochondrial disorder that robs the body's cells of energy, in turn causing progressive multiple organs (brain, nerves, liver, intestines ...

Prince Frederik of Luxembourg has died at the age of 22 from POLG mitochondrial disease, a rare genetic disorder that he was born with, his family announced. Frederik de Nassau died in Paris on ...

The findings come from a post hoc analysis of the HEALEY ALS Platform Trial, comparing CNM-Au8 to a concurrently enrolled control. Strong survival benefit was observed in patients meeting the planned ...