We resolved four structural states at 2.99 to 3.65 Å resolution which are primarily differentiated by varying degrees of solvent accessibility to the active sites and reveal the full dimerization ...

Our biochemical experiments show that GAS2 promotes microtubule nucleation and polymerization, and that its C-terminal region is essential for dimerization, bundling of both F-actin and microtubules, ...

为拓展细胞工程工具盒，研究人员开展了关于转录后合成受体平台的研究。他们建立了 LIDAR（Ligand-Induced Dimerization-Activating RNA editing）平台，该平台兼容性强、功能多样，有望推动基础研究和治疗应用。 受转录合成受体的启发，并希望对其进行补充以扩展细胞 ...

Department of Chemistry, University of Illinois Urbana−Champaign, Urbana, Illinois 61801, United States Beckman Institute for Advanced Science and Technology, University of Illinois Urbana−Champaign, ...

Analysis by SC-XRD revealed that the crystal did not contain ROY itself, but the meso-diastereomer of a molecule formed via an oxidative dimerization of ROY (Figure 4). We postulated that the observed ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Type I Interferonopathy-associated variants of ...

The prevalence of antimicrobial-resistant pathogens significantly limited the number of effective antibiotics available clinically, which urgently requires new drug targets to screen, design, and ...

The 5-hydroxytryptamine 2C receptor (5-HTR2C) is a class G protein-coupled receptor (GPCR) enriched in the hypothalamus and the brain stem, where it has been shown to regulate energy homeostasis, ...

In combination with hydrogen/deuterium-exchange, solution scattering data and DNA-binding experiments, our studies reveal a light-sensitive interaction between the LOV and basic region leucine zipper ...