接着，研究人员探究了棕榈酰化是如何促进炎症小体形成的。通过活细胞显微镜观察，他们发现，受到 NLRP3 激活剂刺激后，NLRP3 会迅速在细胞质中形成具有动态、液体样行为的斑点，这和液 - 液相分离（LLPS）的特征相符。而且这个过程完全依赖于棕榈酰化，没有棕榈酰化的 NLRP3 无法形成斑点，也不能支持炎症小体激活。

NLRP3 is a member of a family of proteins known as inflammasome receptors and is a key component of the NLRP3 inflammasome, which is implicated in a host of diseases characterised by runaway ...

He takes over at NodThera shortly after the company reported positive results from a phase 1b/2a clinical trial of NT-0796 – its oral, brain-penetrant NLRP3 inflammasome inhibitor – in ...

The IL-1 family, including IL-1β and IL-18, further exacerbates tissue damage by activating the NLRP3 inflammasome, a mechanism implicated in SLE2,3. These cytokines not only drive local inflammation ...

该成果研究NLRP3炎症小体的激活机制，发现信号诱导的NLRP3相分离是其激活的关键，且棕榈酰转移酶ZDHHC7介导的NLRP3棕榈酰化起重要作用，为理解NLRP3激活及相关疾病治疗提供了新方向。 NLRP3炎症小体属于细胞质内的超分子复合物，主要由受体NLRP3蛋白、接头蛋白ASC ...

*仅供医学专业人士阅读参考肿瘤的放射治疗不仅能直接杀伤肿瘤细胞，还能通过释放肿瘤相关抗原和损伤相关分子模式（DAMPs）激活免疫反应。然而，放疗单独应用时，其诱导的全身性抗肿瘤免疫往往不足以实现长期疗效。为提高放疗的免疫激活效果，近年来科学家积极探索 ...

The KC inflammasome is activated to promote the secretion of interleukin-18 (IL-18) by KCs. Simultaneously, the translocation of HMGB1 from the nucleus to the cytoplasm activates the receptor for ...

Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common chronic liver disease globally and is currently estimated to affect up to 38% of the global adult population. NAFLD is a ...

A new year means a new Fierce Biotech Fundraising Tracker to record the significant amounts of venture capital being funneled into the industry. We're maintaining the criteria we used for last ...